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结直肠癌组织中Kindlin-2、E-cadherin和MMP-9表达研究

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摘要 目的:观察结肠癌术后组织中Kindlin-2、E-cadherin和MMP-9的表达及对预后的判断价值。方法:应用流式细胞术探讨结肠癌和正常结肠粘膜组织中Kindlin-2、E-cadherin和MMP-9蛋白的表达及临床意义。结果:结直肠癌中Kindlin-2和MMP-9的表达量明显高于对照组,E-cadherin的表达量明显低于对照组,结直肠癌中Kindlin-2、E-cadherin和MMP-9的表达量与Dukes分期、淋巴结转移、Ki67的表达密切相关。结论:结直肠癌中Kindlin-2、E-cadherin和MMP-9异常表达对肿瘤的进展有重要意义。
机构地区 丽水市中心医院
出处 《中国高等医学教育》 2013年第5期122-123,共2页 China Higher Medical Education
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