Necdin与神经系统退行性改变

The relationship between Necdin and degenerative changes in the nervous system

Necdin是黑素瘤相关抗原家族II成员之一,主要表达于成熟神经元的细胞核。Necdin作为一种生长抑制蛋白,通过与多种胞核及胞浆中的细胞因子结合,调控细胞周期、细胞分化及细胞凋亡过程。人类Necdin基因位于Prede-Willi综合征(PWS)的基因缺失区,可能与PWS的一些症状有关。Necdin缺失的小鼠表现出运动缺陷,可能参与了神经退行性改变。本文就Necdin的对神经系统的影响做一综述。

Necdin is one of the melanoma-associated antigen gene expression （MAGE） family proteins, mainly expressed in nucleus of postmitoticneurons. As a growth suppressor, it has been shown to interact with both nuclear and cytoplasmic proteins to regulate cell cycle, apoptosis and cell differentiation. The necdin gene is localized to the Prader -Willi syndrome deletion region, and may contribute to some symptoms of Prader-Willi syndrome （PWS）. Necdin-deficient mouse have a motor deficit, which suggests necdin participates in neurodegeneration. Here we introduce necdin from the aspect of its influence to the nervous system.