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14-3-3蛋白与突触核蛋白磷酸化的研究进展

Research Progress on the Relationship between 14-3-3 and α-Synuclein Phosphorylation
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摘要 α-SYN是第一个被鉴定的帕金森病(Parkinson`s disease,PD)致病基因。其蛋白α-Synuclein主要存在于PD病人的神经元胞质内包涵体———路易小体(Lewy bodies,LBs)中;而14-3-3蛋白在真核细胞的信号转导中发挥着非常重要的作用。本文综述了14-3-3蛋白与α-Synuclein相互作用的研究进展,并推测14-3-3蛋白在α-synuclein的磷酸化过程中扮演着重要的角色。 α-SYN was identified as the first gene of Parkinson＇s disease, α-Synuclein mainly in Lewy bodies, which are abnormal aggregates（cytoplasmic inclusions） of protein that develop inside nerve cells in PD. 14-3-3 protein plays a common role in eukaryotic signal transduction. This article reviews the research on the relationship between 14-3-3 and α-Synuclein, and assumes that 14-3-3 plays an important role in α-Synuclein phosphorylation.
作者 陶瑞松 王伟
机构地区 合肥师范学院生命科学系
出处 《合肥师范学院学报》 2013年第3期43-44,共2页 Journal of Hefei Normal University
基金 2011年安徽省高校省级优秀青年人才基金一般项目"14-3-3蛋白在α-synuclein磷酸化中的作用"(2011SQRL131)
关键词 帕金森病 14-3-3蛋白 突触核蛋白 Parkinson＇ s disease 14-3-3 α-Synuclein
分类号 R592 [医药卫生—老年医学]
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参考文献18

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合肥师范学院学报
2013年 第3期

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