25-羟维生素D水平与妊娠期细菌性阴道病发生率的关系

The Relationship between the Level of 25-(OH) D and the Incidence Rate of Pregnancy Bacterial Vaginal Disease

目的:探讨妊娠妇女血清25-羟维生素D水平与妊娠期细菌性阴道病(BV)发生率的关系。方法:对2011-2012年来笔者所在医院进行产检的妊娠期10～12周及24～28周的孕妇各400例进行血清25-(OH)D检测,并取阴道分泌物进行BV检查,对其相关性进行分析。结果:笔者所在地区孕10～12周孕早期妇女25-(OH)D缺乏(≤50.0nmol/L)的发生率为52.3%,25-(OH)D不足(50.0nmol/L<25(OH)D≤75.0nmol/L)的发生率为30.5%,25-(OH)D正常者(>75.0nmol/L)占17.3%,其相对应的BV的发生率分别为32.1%、23.8%、5.8%。妊娠24～28周孕晚期妇女25-(OH)D缺乏的发生率为61.8%,25-(OH)D不足的发生率为32.8%,25-(OH)D正常者占5.5%,其相对应的BV的发生率分别为40.9%、32.1%、9.1%。对两组进行比较,妊娠24～28周孕妇25-(OH)D异常高于孕10～12周,维生素D下降明显,相对应出现BV感染率显著高。25-(OH)D不足和缺乏的孕妇中BV发生率高于25-(OH)D正常的孕妇(P<0.05)。结论:妊娠期细菌性阴道病的发生率与25-羟维生素D缺乏密切相关。

Objective： To discuss the relationship between the level of pregnant women＇s serum 25-（OH）D and the incidence rate of pregnancy bacterial vaginal disease （BV）.Methods： All the 400 cases of the pregnant women for the gestation period in 10-12 and 24-28 weeks from 2011 to 2012 in our hospital were selected.All the pregnant women were examined the test of the serum 25-（OH）D and the BV inspection.To analyse the correlation between the test of the serum 25-（OH）D and the BV inspection.Results： In local region, the incidence rate was 52.3% when 25-（OH）D was deficiency（≤50.0 nmol/L） for 10-12 weeks early pregnant women, 30.5% when it was shortage（50.0 nmol/L〈25-（OH）D≤75.0 nmol/L） and 17.3% was normal（〉75.0 nmol/L）, which relevant incidence rate of BV was 32.1%, 23.8% and 5.9%.On the other hand, the incidence rate was 61.8% when 25-（OH）D was deficiency for 24-28 weeks late pregnant women, 32.8% when it was shortage and 5.5% was normal, which relevant incidence rate of BV was 40.9%, 32.1% and 9.1%.The 25-（OH）D in 24-28 weeks nf pregnancy appear obvious anomaly more than 10-12 weeks pregnant women, Vitamin D down significantly, BV infection rate increased significantly.BV incidence in 25-（OH）D deficiency and lack were patency higher than the 25-（OH）D normal（P〈0.05）.Conclusion： The incidence rate of pregnancy bacterial vaginal disease is closely related to the deficiency of Vitamin D in pregnant women.