哮喘与钙库操纵钙离子内流的关系研究进展

Advances of the relationship of asthma and store-operated calcium

支气管哮喘是严重影响人类日常生活的慢性疾病之一，近年来全世界范围内儿童哮喘发病呈逐年上升的趋势，但目前哮喘的发生机制仍未十分明确。研究发现钙库操纵钙离子内流（store-operated calcium entry，SOCE）在机体生理活动中起着重要作用，在细胞生长中，SOCE活性的增强可以促进多种类型细胞的增殖、增生以及迁移，其中构成SOCE重要分子的基质相关作用因子1（stromal interaction mole—cule1，STIM1）和钙离子释放激活钙离子通道蛋白1（calcium release-activated calcium channel protein1，ORAI1）可能参与哮喘气道高反应性的发生及气道的重塑，与支气管哮喘的发生、发展有密切关系。

As one of the chronic diseases, asthma,plays a serious impact on human daily life. Asthma in children has showed an increasing trend in recent years, but the mechanisms of asthma are not yet clear. Studies have found that store-operated calcium entry（SOCE） plays an important role in the physiological activity of the body. The enhanced SOCE activity can promote cell growth, proliferation, and migration of a variety of cell types. SOCE important molecules STIM1 and ORAI1 may be involved in the asthmatic airway occurrence of hy-perresponsiveness and airway remodeling, and closely to the asthmatic development.