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肺表面活性物质相关蛋白A与肺部免疫应答的关系 被引量：4

Pulmonary surfactant-A and immune response in lung
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摘要 肺表面活性物质（PS）由肺表面活性物质相关蛋白及脂质组成，其功能除了可减少肺泡表面张力，从而防止呼气时肺泡萎陷外，还可参与肺部免疫应答。PS相关蛋白A（SP—A）作为其组成成分之一，通过调理作用、直接促进免疫细胞吞噬、调节细胞表面受体表达、参与调节适应性免疫反应细胞等方式在肺免疫应答方面发挥重要作用。鉴于SP—A在肺部免疫中的作用，SP—A的替代或促进SP-A的生成，将能更好地治疗肺部炎症及感染性疾病。 Pulmonary surfactant is a complex mixture of lipids and surfactant proteins （SP） lining the alveolar surface. In addition to the well established ability of the surfactant system to reduce alveolar surface ten-sion and thereby prevent collapse of the alveoli on expiration,it is also involved in pulmonary host defence. Sur-facant protein-A （ SP-A）, one of the most abundant SP, can deal with various pathogens, using a range of innate immune mechanisms,and links innate immunity with adaptive immunity that includes modulation of dendritic cell function and helper T cell polarization. Surfactant-replacement or increasing SP-A generation might be effi-cacious for the treatment of inflammatory and infectious diseases in the lung.
作者 黄霞(综述) 赵德育(审校)
机构地区 南京医科大学附属南京儿童医院呼吸科
出处 《国际儿科学杂志》 2013年第3期240-242,共3页 International Journal of Pediatrics
关键词 肺表面活性物质 免疫功能 炎症 Pulmonary surfactant Immune function Inflammation
分类号 R392.12 [医药卫生—免疫学]
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参考文献26

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二级参考文献23

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共引文献31

同被引文献53

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引证文献4

二级引证文献25

国际儿科学杂志
2013年 第3期

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