脑钠肽在小儿先天性心脏病及围手术期的应用进展

Progress in use of brain natriuretic peptide in congenital heart disease and perioperative pediatric cardiac operation

脑钠肽是一种神经内分泌激素，它与先天性心脏病患儿心功能不全和肺动脉高压程度呈正相关，已成为评估先天性心脏病息儿心功能不全程度、反映先天性心脏病患儿术前术后心功能状态的简便、准确的生物化学指标。它对先天性心脏病心脏手术预后有预测作用，对围手术期治疗有指导意义，能减少术后并发症和病死率，成为迅速、即时床边检查的辅助手段。该文就其与先天性心脏病的相关性和在先天性心脏病围手术期应用进展作一概述。

Brain natriuretic peptide（BN-P） is a neuroendocrine hormone, which has a positive correlation with degree of cardiac dysfunction and pulmonary arterial hypertension of children with congenital heart disease （CHD）. BNP has been shown to be a simple, accurate and useful biochemical indicator in assessing cardiac dys-function degree and reflecting perioperative cardiac function state of children with CHD. It has prognostic value in congenital heart surgery and can guide the perioperative treatment and reduce the postoperative complications and mortality. It is a quick, instant bedside inspection supplementary means. This article describes the relevance between BNP and CHD and the application progress of BNP in perioperative of CHD.