摘要
大动脉炎是主动脉和肺动脉及其主要分支的慢性非特异性炎症，儿童患者的症状和体征常不典型，多为高血压、发热、关节炎和消瘦等非特异性表现。欧洲抗风湿病联盟和欧洲儿童风湿病学会提出了更适用于儿童的诊断标准，血管造影异常是诊断的必备条件，可以早期诊断并且监测疾病活动程度。其治疗除了传统的激素和免疫抑制剂以外，近年来一些新的免疫抑制剂以及生物制剂也取得了很好的疗效。
Takayasu arteritis （TA） is a devastating vasculitis of the aorta and its major branches, coro-nary and pulmonary arteries. The clinical manifestations in children are less specific than in adults：the disease in children presents with fever, arthralgias, vomiting, weight loss and hypertension. Conventional angiography, which is recognized as the golden standard in evaluating vascular lesions in TA,combined with computer tomo- graphy angiography （CTA） ,magnetic resonance angiography （ MRA）, ultrasonography, could not only provide important information for early diagnosis, but also detect disease activity. New immunosuppressive agents and bi-ological therapies, such as TNF-a blocking agents, have been verified to be effective although corticosteroids and conventional immunosuppressive agents are still basic treatment.
出处
《国际儿科学杂志》
2013年第3期297-300,共4页
International Journal of Pediatrics
关键词
大动脉炎
儿童
诊断
治疗
Takayasu arteritis
Children
Diagnosis
Treatment.
