摘要
以国产醋酸去氢表雄酮 (2 )为起始原料 ,经水解、磺酸酯化和成盐三步反应 ,顺利合成得到子宫颈管促进成熟剂硫酸普拉睾酮钠二水合物 (1) ,以醋酸去氢表雄酮 (2 )计算总收率为 84 %。
With dehydroisoandrosterone acetate (2) as the starting material, Prasterone sulfate sodium dihydrate (1) was synthesized after three steps reactions of hydrolysis, sulfonylation and salt formation, The overall yield was 84% taken as dehydroisoandrosterone acetate(2).
出处
《广东药学院学报》
CAS
2000年第3期181-182,共2页
Academic Journal of Guangdong College of Pharmacy
关键词
硫酸普拉睾酮钠
合成
二水合物
Prasterone sulfate sodium dihydrate
synthesis
uterine cervix maturative agent
steroid d8
