抗凝疗法改善慢性阻塞性肺疾病血液流变学的作用

Effects of Anticoagulant Therapy on Hemorheology in Patients with Chronic Obstructive Pulmonary Diseases

目的 :探讨抗凝疗法改善慢性阻塞性肺疾病血液流变学的作用。方法 :慢性阻塞性肺疾病病人 110例随机分为治疗组 58例 ,对照组 52例。二组病人均给予吸氧、扩张支气管、祛痰、抗炎等常规治疗 ,治疗组加用注射用降纤酶 5u溶于生理盐水 10 0mL中静脉滴注 ,隔日 1次 ,共 14d。观察治疗前后血液流变学和临床症状的变化。结果 :血液流变学各项指标和临床症状 ,治疗组治疗前后相比有显著改善 ,对照组无显著性改变。结论 :抗凝治疗可降低血液粘度 ,疏通微循环 ,缺氧和高碳酸血症得以改善 ,有利于病情好转。

Objective: To investigate the effects of Anticoagulant therapy on hemorheology in patients with chronic obstructive pulmonary disease(COPD). Methods: 110 patients with COPD were randomly divided into two groups:58 in treatment group and 52 in control group. Oxygen, bronchrodilator, mucokinetic agents and antibiotics were administered in all patients. Defibrase was added in treatment group. Changes of Hemorheology and clinical symptoms were observed before and after treatment. Results: There was an obvious improvement in clinical symptoms and the indices of hemorheology after treatment in the treatment group compared to the control group. Conclusion: Anticoagulant therapy can decrease blood viscosity and improve microcirculation, hypoxemia and hypercapnia.