乳酸左氧氟沙星泡腾片的制备及质量考察

Study on preparation of effervescent tablets of levofloxacin lactate and its quality

目的:研究乳酸左氧氟沙星泡腾片，以方便老人及吞咽困难的患者服用，为开发乳酸左氧氟沙星制剂新品种奠定基础。方法:用酸、碱分开制法制备乳酸左氧氟沙星泡腾片，并对其性状、重量差异、崩解时限、酸度、鉴别、含量测定、稳定性等进行了检测。结果:本品处方、制备工艺简单，质量优良，稳定、易控制，适口性强。结论:本品可作为乳酸左氧氟沙星制剂新品种开发使用。

OBJECTIVE：To prepare an effervescent tablets of levofloxacin lactate for the elder and the patients with swallow difficulties.ETHODS：Its character、weight deviation、disintegration time、pH、content stability were tested.ESULTS：The preparation method is simple,the tablet is stable with delicious taste.CONCLUSIONS：It is valuable to be further studied as a new prepa ration of levofloxacin lactate.