川丹口服液对急性血瘀模型大鼠血液流变学的影响

Effect of Chuandan oral solution on hemorrheology of the acute blood stasis rats model

目的:研究川丹口服液对急性血瘀模型大鼠血液流变学的影响。方法:通过给大鼠注射大剂量盐酸肾上腺素注射液模拟“暴怒”状态，以冰水浸泡模拟“寒邪”侵袭，使动物迅速形成血瘀状态，采用预防性实验治疗，即预先分别给大鼠灌服川丹口服液和尼莫地平片各8 d，然后测定血液流变学。结果:川丹口服液可显著降低实验性大鼠高、中、低切变率下全血粘度及血浆粘度、全血还原粘度、红细胞压积。结论:川丹口服液能显著改善急性血瘀模型大鼠血液流变学异常。

OBJECTIVE：To study the effect of chuandan oral solution on hemorrheology of the acute blood stasis rats model.METHODS：The rats model of blood stasis were made by injecting large dose suprarenalin in the rats first and then immersing the rats in ice water to make the rats in fury and cold tathogenic invading situations.When the model established, Chuandan oral solution and nimodipine were given to the rats for 8 days.The hemorrheology of the rats were measured. RESULTS： Chuandan oral solution could significantly decrease blood viscosity of high、medial、low shearing rate as well as plasma and blood reductus viscosity.It decreased blood hematocrit of the experimental rats,too.CONCLUSIONS： Chuandan oral solution can significantly improve hemorrheology of the acute blood stasis rats.