糖络宁治疗糖尿病周围神经病变临床研究

Clinical research on patients of diabetic peripheral neuropathy treated with Tangluoning

目的:客观评价糖络宁治疗糖尿病周围神经病变(DPN)的临床疗效,并对其作用机制进行初步探讨。方法:将符合诊断标准的210例DPN病人,随机分为治疗组(105例)和对照组(105例),治疗组用糖络宁复方免煎颗粒口服,对照组用甲钴胺片口服治疗。重点观察两组患者的中医临床症状、坐骨神经传导速度、神经病变积分等指标治疗前后变化。结果:治疗组的总有效率为89.9%,对照组的总有效率为71.4%,经Ridit检验显示,治疗组的疗效明显优于对照组(P<0.05);治疗组主侧感觉神经及运动神经传导速度改善均优于对照组(P<0.05);治疗组患者血清超氧化物歧化酶水平明显高于对照组(P<0.05),治疗组患者血清丙二醛水平明显低于对照组(P<0.05);治疗过程中没有明显的不良反应出现,无肝肾功能损害。结论:中药糖络宁可明显改善DPN患者的临床症状、神经病变积分及神经传导速度,其作用机制可能与改善机体氧化应激状态有关。

Objective： To observe the therapeutic effects and antioxidative effect of Tangluoning （TLN） on diabetic peripheral neuropathy （DPN）. Methods： 210 DPN patients who were confirmed to the diagnostic criteria were randomly divided into the treatment group （105 patients） and control group （105 patients）. On the basis of routine treatment, the patients in treatment group were given TLN. The patients in control group were given methycobal. The changes of symptoms, nerve conductive velocity and the content of malonaldehyde （MDA）, the activity of superoxide dismutase （SOD） were observed in both groups. Results： The total effective rate of treatment group was 89.9%, which was obviously superior to that in control group （71.4%） （P〈0.05）. There were significant differences in the improvement of nerve conductive velocity between two groups （P〈0.05）. After treatment, MDA content decreased significantly and the level of SOD increased significantly in both groups （P〈0.05）, oxidative stress reactions of patients in both two groups were significantly improved and the effect of treatment group was superior to that of control group, the difference was significant （P〈0.05）. There were no obvious side effects during the treatment. Conclusion： TLN could obviously improve therapeutic effect on DPN by protecting against oxidative stress.