化痰通络汤合牵正散对风痰瘀血痹阻证急性脑梗死患者同型半胱氨酸的影响及临床疗效观察

Influence of httlt with QZS on homocysteine and the clinical efficacy on patients with acute cerebral infarction of ‘wind phlegm and blood stasis stagnation collaterals syndrome’

目的:观察化痰通络汤合牵正散对风痰瘀血痹阻证急性脑梗死患者同型半胱氨酸的影响及临床疗效。方法:选择符合中西医诊断标准及辨证属风痰瘀血痹阻证的急性脑梗死病人160例,随机分治疗组和对照组各80例,治疗组用化痰通络汤合牵正散加常规西医治疗法,对照组用常规西医治疗法,3周后评定疗效。比较两组治疗前后中医证候积分,神经功能缺损评分及同型半胱氨酸水平。结果:治疗组在临床疗效、调节同型半胱氨酸方面优于对照组(P<0.05)。结论:化痰通络汤合牵正散能提高风痰瘀血痹阻证脑梗死的临床治疗效果,降低同型半胱氨酸水平,对急性脑梗死的防治提供了新的方向。

Objective： To observe the effect of Huatan Tongluo Decotion（HTTLT）with Qianzheng San（QZS）on homocysteine in patients with acute cerebral infarction of ＇wind phlegm and blood stasis stagnating collaterals syndrome＇ and its clinical efficacy. Methods： 160 patients with acute cerebral infarction belonging to ＇wind phlegm and blood stasis stagnation collaterals syndrome＇ were selected by the traditional Chinese and western medicine diagnosis standard, and randomly divided into the treatment group and the control group with 80 cases for each. The treatment group were treated with HTTLT with QZS and the routine western medicine therapy, while the control group were treated with the routine western medicine therapy only, evaluating the curative effect three weeks later. Comparing the TCM syndrome score, the Neural function defect score and the homocysteine level before and after treatment between the two groups. Results： The treatment group was better than the control group in the clinical efficacy and in regulating the homocysteine level （P〈0.05）. Conclusion： HTTLT with QZS could improve the clinical treatment effect of cerebral infarction belonging to ＇wind phlegm and blood stasis stagnation collaterals syndrome＇, and reduce the homocysteine level, which provided a new direction for the prevention and treatment of cerebral infarction.