自拟康肾口服液对水负荷大鼠模型的影响

Influence of Self-designed Kangshen oral solution on the rat model of water load

目的研究康肾口服液对水负荷大鼠模型的影响。方法体重180～200 g Wistar大鼠,雄性,72只,随机分为6组,分别灌服康肾口服液、尿毒清颗粒混悬液、呋塞米片混悬液和同体积的生理盐水。测尿液中Na+、K+、Cl-的浓度。结果水负荷大鼠模型成功建立。与模型组比显著增加大鼠尿液量(P<0.01),可显著增加尿液中尿钠离子含量(P<0.01),可显著增加尿液中尿氯离子含量(P<0.01),可显著增加尿液中尿钾离子含量(P<0.01)。结论康肾口服液有显著的利尿作用,且优于尿毒清颗粒、呋塞米片。

Objective To study the influence of self-designed Kangshen oral liquid on the rat model of water load. Methods The 72 Wistar rats （weight： 180 to 200 g, male） were randomly divided into 6 groups： irrigation of Kangshen oral solution, of Niaoduqing granule suspension, of furosemide tablets suspension and the same volume of physiological saline. The urine Na＋, K＋, Cl- levels were detected. Results The water load in a rat model was of success.Compared with the model group, there was a significant increase in urine volume in other groups of rats（P〈0.01）, and significant increase of urinary sodium ion level in urine（P〈0.01）, significant increase of urine urinary chloride ion level （P〈0.01） and significantl increase of the urinary potassium ion level in urine （P〈 0.01）. Conclusion Kangshen oral solution has a significant diuretic effect, and is superior to uremic clearance granule, furosemide tablets.