度洛西汀与西酞普兰治疗重性抑郁症对照研究

A control study of duloxetine vs. citalopram in the treatment of major depression

目的探讨度洛西汀与西酞普兰治疗重性抑郁症的临床疗效和安全性。方法将58例重性抑郁症患者随机分为两组，每组29例，分别口服度洛西汀、西酞普兰治疗，观察8周。采用汉密顿抑郁量表和副反应量表评定疗效及不良反应。结果度洛西汀组起效时间显著快于西酞普兰组（t=3．19，P〈0．01），显效率显著高于西酞普兰组（x2=4．08，P〈0．05）。两组不良反应较轻微，发生率比较差异无显著性（P〉O．05）。结论度洛西汀治疗重性抑郁症疗效显著，较西酞普兰起效更快，且安全性高，依从性好。

Objective To explore the clinical efficacy and safety of duloxetine vs. venlafaxine in the treatment of major depression （MD）. Methods Fifty-eight MD patients were randomly divided into two groups of 29 ones each, they took o- rally duloxetine or venlafaxine for 8 weeks. Efficacies were assessed with the Hamilton Depression Scale （HAMD） and adverse reactions with the Treatment Emergent Symptom Scale （TESS）. Results Duloxetine took effect more rapidly than venlafaxine did （t=3.19, P〈0.01）, obvious effective rate o{ the {ormer was significantly than that of the latter （x2 =4.08, P%0.05）. Adverse reac- tions of both groups were mild, there were no significant differences in their incidences （P〈0.05）. Con- elusion Duloxetine has an evident effect, takes effect more rapidly, and has higher safety and better com- pliance compared citalopram in the treatment of major depression.