合欢皮有效部位胶囊制剂处方筛选及稳定性研究

Formulation and stability studies of Albizia effective component capsules

目的筛选合欢皮有效部位胶囊制剂最佳处方及制剂的初步稳定性研究。方法运用湿法制粒,通过对胶囊内容物成型效果、粒度不合格率、水分含量、溶化性和流动性的检测筛选出合欢皮有效部位胶囊制剂的制剂工艺。并在不同条件下进行稳定性研究。结果经筛选所得处方制备的胶囊胶囊内容物颜色均一,溶化性好,所填充得到的胶囊能迅速崩解,稳定性好。结论此胶囊崩解迅速,制备工艺简单,稳定性好。

OBJECTIVE To Screen the best prescription of Albizia effective component capsules and study on the preliminary stability.METHODS wet granulation was used to detect,molding effect of the capsule contents,particle size of the failure rate,moisture content,disolubility,and mobility for screening technique of Albizia effective component capsule.Then obtaine the stability studies under different conditions.RESULTS The screened formulation had uniform color,good deliquescence,rapide disintegration and good stability.CONCLUSION The capsules disintegration is rapid,simple preparation,good stability.