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渗透性表面面积指数对幕上脑出血早期血肿扩大的预测研究 被引量:3

Study of the Correlation Between Permeability-Surface Area Product and Hematoma Expansion in Acute Intracerebral Hemorrhage
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摘要 目的 探讨渗透性表面面积指数(permeability-surface area product index,PSI)预测幕上脑出血早期血肿扩大的敏感程度。方法 连续入组2007年9月~2012年4月首都医科大学附属北京天坛医院急性幕上脑出血患者40例(发病6h内),比较入院时及发病24h时的计算机断层扫描(computedtomography,CT)的血肿体积,根据血肿体积增加是否大于33%者分为血肿扩大组和未扩大组。通过计算机断层扫描血管成像(computedtomographyangiography,CTA)的点征和灌注CT的渗透性表面面积及PSI,比较PSI预测血肿扩大的灵敏度及特异度。结果 血肿扩大的发生率为45%,血肿扩大组水肿组织PSI为(2.600.51)高于未扩大组(2.270.34)(P=0.040);水肿组织PSI诊断血肿扩大的灵敏度为88.89%,特异度为68.18%。结论 脑出血急性期血肿扩大后PSI增加,PSI预测幕上脑出血急性期血肿扩大敏感性高。 Objective To investigate the sensitivity between permeability-surface area product index and hematoma expansion in acute intracerebral hemorrhage. Methods Forty patients with acute intracerebral hemorrhage(onset within 6 hours) who hospitalized in Beijing Tiantan Hospital from September 2007 to April 2012 were included in this study. Computed tomography(CT) perfusion was taken within 6 hours after the patients' symptom onset, and CT scan was rechecked at 24 hours after the patients' symptom onset. The correlation between permeability-surface area product and hematoma expansion was evaluated. Results The incidence rate of hematoma enlargement was 45%. The permeability-surface area product index(PSI)(2.60±0.51) of the edema tissue of patients with hematoma enlargement was bigger than those without(2.27±0.34)(P=0.040). In the diagnosis of hematoma enlargement, the sensitivity of PSI of edema was 88.89%, the specificity was 68.18%. Conclusion In the acute phase of cerebral hemorrhage, PSI is increased, and PSI is very sensitive in prediction of the occurrence of hematoma enlargement.
出处 《中国卒中杂志》 2013年第5期334-339,共6页 Chinese Journal of Stroke
关键词 脑出血 急性期 血肿 渗透性表面面积 计算机断层扫描灌注显像 Cerebral hemorrhage Acute phase Hematoma expansion Permeability-surface area product Computed tomography perfusion
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参考文献13

  • 1Davis SM, Broderick J, Hennerici M, et al. Hematoma growth is a determinant of mortality and poor outcome after intracerebral hemorrhage[J]. Neurology, 2006, 66:1175-1181.
  • 2Kazui S, Naritomi H, Yamamoto H, et al. Enlargement of spontaneous intracerebral hemorrhage:incidence and time course[J]. Stroke, 1996, 27:1783-1787.
  • 3Broderick JP, Brott TG, Duldner JE, et al. Volume of intracerebral hemorrhage:a powerful and easy-to-use predictor of 30-day mortality[J]. Stroke, 1993, 24:987- 993.
  • 4Goldestein JN, Fazen LE, Snider R, et al. Contrast extravasation on CT angiography predicts hematoma expansion in intracerebral hemorrhage[J]. Neurology, 2007, 68:889-894.
  • 5各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-380. 被引量:33008
  • 6Fujitsu K, Muramoto M, Ikeda Y, et al. Indications for surgical treatment of putaminal hemorrhage:Comparative study based on serial CT and time-course analysis[J]. J Neurosurg, 1990, 73:518-525.
  • 7王文娟.脯出血临床预后相关分析及脑出血急性期脑容积分层管理策略的前期研究【D].北京:首都医科大学,2011.
  • 8赵性泉.一站式多模式CT在脑出血诊疗中的应用[J].中华医学杂志,2012,92(31):2171-2173. 被引量:8
  • 9Brott T, Broderick J, Kothari R, et al. Early hemorrhage growth in patients with intracerebral hemorrhage[J]. Stroke, 1997, 28:1-5.
  • 10王顺蓉,张英,李著华.血脑屏障的结构与功能研究进展[J].四川生理科学杂志,2005,27(2):88-89. 被引量:17

二级参考文献10

  • 1van Asch CJ, Luitse MJ, Rinkel GJ, et al. Incidence, case fatality, and functional outcome of intracerehral haemorrhage over time, according to age, sex, and ethnic origin:a systematic review and meta-analysis. Lancet Neurol,2010,9 : 167-176.
  • 2Zazulia AR, Diringer MN, Derdeyn CP, et al. Progression of Mass Effect after Intracerebral Hemorrhage. Stroke, 1999, 30 : 1167- 1173.
  • 3Mizukami M, Araki G, Mihara H, et al. Extravasation of contrast media in hypertensive cerebral hemorrhage--discussion on the mode of the growth of massive hematoma and proposal of constructive surgery. No To Shinkei, 1971,23:1359-1367.
  • 4Kowada M, Matsuoka S, Ito Z, et al. Early surgical treatment of hypertensive cerebral hemorrhage with extravasation. No ToShinkei, 1971,23 : 1353-1357.
  • 5Mayer SA, Brun NC, Begtrup K, et al. Efficacy and safety of recombinant activated factor Ⅷ for acute intracerebral hemorrhage. N Engl J Med,2008,358:2127-2137.
  • 6Anderson CS, Huang Y, Arima H, et al. Effects of early intensive blood pressure-lowering treatment on the growth of hematoma and perihematomal edema in acute intracerebral hemorrhage: the intensive blood pressure reduction in acute cerebral haemorrhage trial (interact). Stroke,2010,41:307-312.
  • 7Delgado Almandoz JE, Yoo A J, Stone MJ, et al. Systematic characterization of the computed tomography angiography spot sign in primary intracerebral hemorrhage identifies patients at highest risk for hematoma expansion : the spot sign score. Stroke, 2009, 40:2994-3000.
  • 8Delgado Almandoz JE, Yoo A J, Stone M J, et al. The spot sign score in primary intracerebral hemorrhage identifies patients at highest risk of in-hospital mortality and poor outcome among survivors. Stroke ,2010,41:54-60.
  • 9Brott T, Broderick J, Kothari R, et al. Early hemorrhage growth in patients with intracerebral hemorrhage. Stroke, 1997,28:1-5.
  • 10Lin K, Kazmi KS, Law M, et al. Measuring elevated microvascular permeability and predicting hemorrhagic transformation in acute ischemie stroke using first-pass dynamic perfusion CT imaging. AJNR Am J Neuroradiol ,2007 ,28 :1292-1298.

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