抗肿瘤抗体药物的研究进展

Progress in anti-tumor antibody drugs

随着生物科技的发展以及对抗体结构与功能的深入研究,抗肿瘤抗体药物历经了裸抗体、单克隆抗体及其衍生物、基因工程抗体三个时代的发展。本文概述了抗肿瘤抗体药物的发展历程及现状、抗肿瘤抗体药物的分类与特点,以及抗体药物治疗肿瘤的基本原理,并且对抗体药物由单一靶点向多靶点、抗体高效小型化、抗体组学与抗体组药物等方向的发展趋势进行了展望。

With the development of biotechnology and deep research of the structure and function of antibodies, the progress of anti-tumor antibody drugs can be summarized three stages： naked antibody, monodonal antibody and its derivatives, and gene engineering antibody. This article ummarizes the progress and current situation of the anti-tumor antibody drugs, the types and characteristics of these drugs, and the basic principle of antibody drug treatment for tumor. In addition, the trends from a single target to multiple antibody targets, the efficiency and miniaturization of antibody drugs and the boom of antibodomic and antibodomic medicine are also discussed.