非酒精性脂肪性肝病与甲状腺功能减退症

Non-alcoholic fatty liver disease and hypothyroidism

非酒精性脂肪性肝病与甲状腺功能异常的发病日渐增多，两者均与环境因素和生活方式有一定关系，但两者之间有否相关，是否与代谢异常有关仍不明确。非酒精性脂肪性肝病患者甲状腺激素水平低下，甲状腺功能减退症发生率增加。甲状腺激素可能通过影响脂代谢、氧化应激、线粒体功能、甲状腺激素受体表达等途径影响脂质在肝脏的沉积。因此，研究非酒精性脂肪性肝病与甲状腺功能异常的发病关系，为研发新型的非酒精性脂肪性肝病治疗药物提供了新的靶点。

The occurrence of nonalcoholic fatty liver disease and thyroid disfunction are increasing, which are both related to enviromnental factor and life style. The real mechanism between them is unknown. Whether they relate to the metabolic disorder need to be further studied. The level of thyroid hormone in pa- tients with nonalcoholic fatty liver was low and the prevalence of hypothyroidism was high. Thyroid hormone can influence on lipid accumulation in the liver by influencing lipid metabolism, oxidative stress, mitochondri- al function and thyroid hormone recepter expression. Verify the pathogenesis in nonalcoholic fatty liver disease and thyroid disfunction will be helpful to find the novel target in the treatment of nonalcoholic fatty liver dis- ease.