重组人生长激素治疗的不良反应

The adverse reactions of recombinant human growth hormone in treatment

生长激素（GH）是人体必需的激素之一。对于生长激素缺乏症（GHD）的儿童，重组人生长激素（rhGH）替代治疗疗效明确，但其仍可引起水钠潴留、良性颅高压、股骨头滑脱、脊柱侧弯、甲状腺功能减退症、糖脂代谢紊乱、继发肿瘤发生的危险性升高等不良反应。对上述不良反应的发生情况、发生机制及其相关的治疗措施等方面进行详细的阐述，有助于指导今后安全用药。

Growth hormone （GH） is one of the essential hormones needed by human body. For chil- dren with growth hormone deficiency （ GHD）, the effect of replacement therapy using recombinant human growth hormone （rhGH） is obvious, but still some adverse reactions can be caused, such as sodium and water retention, benign intracranial hypertension, slipped capital femoral epiphysis, scoliosis, hypothyroidism, glu- cose and lipid metabolism disorder, increasing risk of secondary neoplasm, etc. Clarifing the occurrences, mechanisms and related treatments of adverse reactions mentioned above is helpful to guide the safe applica- tion of medication in the future.