黑棘皮病与青少年肥胖

Acanthosis nigerians and adolescent obesity

黑棘皮病是青少年肥胖患者中常见的皮肤病变，是青少年肥胖患者体内严重胰岛素抵抗的皮肤标志。在肥胖患者中，高胰岛素血症、炎性反应因子、异常分泌的脂肪细胞因子可促进皮肤组织内的成纤维细胞及角蛋白细胞的增殖，从而促进黑棘皮病的发生。另外，基因多态性同样在这一过程中发挥重要作用。然而青少年肥胖患者黑棘皮病的治疗尚无特效方法，通过饮食、运动及药物改善内胰岛素敏感性可能有效。

Acanthosis nigricans is a common cutaneous disorder in adolescent patients with obesity, which is a cutaneous marker of severe insulin resistance in this population. In obese patients, hyperinsuline- mia, inflammatory factors and abnormal secretion of adipocytokines can promote cellular proliferation of fibro- blasts and keratinocytes in the cutaneous tissue,thereby facilitate the development of aeanthosis nigricans. In addition, gene polymorphism also plays an importan~ role in this process. However,there is no effective thera- py of acanthosis nigricans in adolescent patients with obesity. Improvement of the insulin sensitivity through diet,sport and medication may have benefit effects on acanthosis nigricans.