醒脑静注射液对急性脑出血患者血清hs-CRP、IL-6的影响

Effects of Xingnaojing Injection on hs-CRP and IL-6 in the Serum of Patients with Acute Cerebral Hemorrhage

目的探讨血清超敏C反应蛋白(hs-CRP)、白介素6(IL-6)与脑出血患者的关系,观察醒脑静注射液对hs-CRP、IL-6的影响,阐明醒脑静注射液治疗脑出血的可能机理。方法将90例急性脑出血患者随机分为试验组和对照组,对照组给予降颅压、止血药等常规治疗,试验组在常规治疗基础上加用醒脑静注射液静滴,于治疗前,治疗第2、3、8、14d,取试验组45例、对照组45例脑出血患者静脉血,采用免疫比浊法检测hs-CRP,电化学发光法检测IL-6。结果 hs-CRP、IL-6呈缓慢下降曲线,醒脑静注射液干预治疗组下降更明显(P<0.05～0.01)。hs-CRP、IL-6值第3天组间比较P<0.05,组间具有显著性差异。结论醒脑静注射液对急性脑出血有明显的治疗作用,可能是一种有效的CRP、IL-6抑制剂和神经保护剂。

OBJECTIVE To explore the relation between hs-CRP, IL-6 in the Serum and acute cerebral hemorrhage, ob serve the influence of Xingnaojing Injection on hs-CRP and IL-6, expound the possible mechanism of Xingnaojing Injection for treating cerebral hemorrhage. METHODS 90 cases with acute cerebral hemorrhage were randomized into experimental group and control group. The control group were given regular treatment with ICP-lowering and styptic drugs. Experimental group were given Xingnaojing Injection on the basis of regular treatment. After 14 days＂ treatment, venous blood of 45 patients in ex- perimental group and 45 patients in control group was drawn. Immunoturbidimetry was applied for detecting hs-CRP and elec- troehemiluminescence was applied for detecting IL-6. RESULTS The change of hs-CRP and IL-6 presented decline curve. The decline in the treatment goup is much more obvious （P〈0.05-0.01）. There was significant difference when the value of hs- CRP and IL-6 on the 3ir day （P〈0.05）. CONCLUSION Xingnaojing Injection has notable therapeutic effects on acute cere- bral hemorrhage and it is probably an effective inhibitor and nervous protective agent of CRP and IL-6.