川丹消斑汤联合西药治疗代谢综合征颈动脉粥样硬化疗效观察

Clinical Observation on ChuanDan XiaoBanTang and Western Medicine in Treating Carotid Atherosclerosis Complicated with Metabolic Syndrome

目的:观察自拟川丹消斑汤联合西药治疗代谢综合征(metabolic syndrome,MS)颈动脉粥样硬化(carotid atherosclerosis,CAS)的临床疗效。方法:将200例MS合并CAS的患者随机分为观察组和对照组各100例,治疗6个月后,观察临床疗效、血液流变学、颈动脉内-中膜厚度、颈动脉斑块厚度积分、心脑血管重要事件的发生及再住院率。结果:血液流变学、颈动脉内-中膜厚度、颈动脉斑块厚度积分观察组治疗前后各指标改善明显(P<0.05);而对照组除血脂外,其他指标治疗前后差异无统计学意义(P>0.05);治疗后观察组总有效率为91%,明显高于对照组的60%,差异具有统计学意义(P<0.01)。结论:川丹消斑汤联用西药治疗代谢综合征所致颈动脉粥样硬化疗效好,且无明显不良反应。

Objective： To observe clinical effects of self-made ChuanDan XiaoBanTang and western medicine in treating carotid atherosclerosis （CAS） complicated with metabolic syndrome （MS）. Method： Two hundred patients were randomized into the observation group and the control group equally, after treating for six months, clinical ef- fects, hemorheology, carotid intima-media thickness, carotid plaque thickness integral, the incidences of cardiovas- cular and cerebrovascular events as well as re-hospitalization rates were explored. Result： The changes of the index- es including hemorheology, carotid intima-media thickness and carotid plaque thickness integral of the observation group were markedly different before and after treating （P〈0.05）; the differences between before and after treating in the indexes of the control group had no statistical meaning except blood fat （P〉0.05）; after treating, total effec- tive rate of the observation group was 91%, remarkably higher than 60% of the control group, the difference had sta- tistical meaning （P〈0.01）. Conclusion： ChuanDan XiooBanTang and western medicine are the therapy effective in treating MS complicated with CAS without obvious adverse reaction.