摘要
CYP3A4是一种重要的药物代谢酶,参与多种药物的体内代谢,该酶的活性在不同的体内,种族和联用药物之间存在着明显的差异。本文综述了CYP3A4酶的基因多态性对药物代谢的影响,以期为指导临床合理用药打下理论基础,确保临床合理用药的安全性和有效性。
CYP3A4 is an important drug metabolizing enzyme involved in the metabolism of a variety of drugs in vivo.The enzymatic activity is significantly different in different individuals and races.In this paper,we summarized the effect of CYP3A4 genetic polymorphism on drug metabolism,in order to lay down a theory foundation for the guidance in clinical rational administration,ensure the safety and effectiveness of clinical usage.
出处
《海峡药学》
2013年第4期1-3,共3页
Strait Pharmaceutical Journal
