胸腺肽对AECOPD并发重症肺炎患者细胞免疫功能的影响

The Effect of thymosin for cellular immune function in acute exacerbation of chronic obstructive pulmonary disease(AECOPD) with severe pneumonia

目的:探讨胸腺肽对慢性阻塞性肺疾病急性发作期(AECOPD)并发重症肺炎患者细胞免疫功能的影响。方法:将60例AECOPD并发重症肺炎的患者随机分为实验组和对照组各30例。采用流式细胞仪检测治疗前、后T淋巴细胞亚群(CD4+及CD8+)及免疫球蛋白IgA、IgG、IgM,实验组30例在常规治疗基础上加胸腺肽80 mg,静脉点滴,每天1次,连续8天为1个疗程。对照组30例接受常规治疗。结果:实验组治疗前,外周血CD4+及CD4+/CD8+下降,CD8+升高,经胸腺肽治疗8天后,外周血CD4+、CD4+/CD8+均明显升高,而CD8+下降,血清免疫球蛋白IgA、IgG、IgM明显增高。治疗前、后及两组间比较,均有显著性差异(P<0.05)。结论:胸腺肽可提高AECOPD并发重症肺炎患者的细胞免疫功能,改善其预后。

Objective ： To investigate the effect of thymosin for cellular immune function in acute exacerbation of chronic ob- structive pulmonary disease （COPD） with severe pneumonia. Method：60 patients of AECOPD with lung infection were randomly divided into treatment group and control group, 30 patients in each group. T lymphocyte subsets （ CD4＋ and CD8＋ ） and immune globulin IgA, IgG and IgM were detected by flow cytometry instrument before and after treatment. Treatment group were added thymosin 80 mg/d ,for 8 days ,on the basic therapy as the conventional group ,Control group received conventional treatment. Results：In treatment group before treatment, CD4,and CD4/CD8 decreased and CDs in- creased,after treatment for 8 days by thymosin, CD4, and CD4/CD8 increased and CDs decreased. IgA, IgG and IgM in- creased. There were statistical differences between before and after treatment and the comparison of two groups （ P 〈 0.05 ）. Conclusion： Thymosin enhances cell immunity of chronic obstructive pulmonary disease with severe pneumonia and improves the prognosis.