CHF患者治疗前后血浆BNP和血清SOD、IL-2检测的临床意义

Clinical Significance of the Changes on Plasma BNP and Serum SOD, IL-2 Levels Both Before and After Treatment in Patients with Chronic Heart Failure

目的:探讨了慢性心力衰竭(CHF)患者治疗前后血浆BNP和血清SOD、IL-2水平的变化及临床意义。方法:应用放射免疫分析对32例CHF患者进行了治疗前后血浆BNP和血清SOD、IL-2测定,并与35名正常健康人作比较。结果:CHF患者在治疗前血浆BNP水平非常显著地高于正常人组(P<0.01),而血清SOD、IL-2水平又非常显著地低于正常人组(P<0.01),经综合治疗2周后则与正常人组比较无显著性差异(P>0.05)。血浆BNP水平与SOD、IL-2水平呈显著负相关(r=-0.5788、-0.6136,P<0.01)。结论:血浆BNP和血清SOD、IL-2水平的变化参与了CHF患者的发生与发展。

Objective To explore the clinical significance of the changes on plasma BNP and serum SOD, IL-2 levels both before and after treatment in patients with CHF. Methods Plasma BNP, serum SOD and IL-2 levels were detected with RIA in 32 patients with CHF and compared to 35 normal healthy controls. Results Before treatment, the plasma BNP levels in CHF patients were significantly higher than those in controls （ P 〈 0.01 ） , hut the serum SOD , IL-2 levels indicated markedly lower than that of controls （ P 〈 0.01 ） . After treatment for 2 weeks, those variables showed almost the same as in controls （ P 〉 0.05 ） , plasma BNP level was negatively eorrelatediy with serum SOD , IL-2 levels （ r = - 0.5788, - 0.6136 , P 〈 0.01 ） . Conclusion The plasma BNP and - um SOD , IL-2 levels were well correlated to the development and progression of CHF.