食欲抑制剂和药物诱导的肺动脉高压

Appetite suppressants and drugs associated pulmonary arterial hypertension

上世纪60年代起,食欲抑制剂与肺动脉高压(PAH)的相关性引起关注。本文综述食欲抑制剂和药物导致的PAH的流行病学资料、临床研究及其导致PAH发病的机制假说,探讨其疾病进展及预后。

In the 1960s,the use of appetite suppressants caused a transient incident of pulmonary arterial hypertension in western countries.Since then the case reports and basic researches have revealed a close relationship between appetite suppressants and pulmonary arterial hypertension.This review describes the epidemic features and clinical studies on appetite suppressant and drug induced pulmonary arterial hypertension,as well as the underlying mechanisms.The progression and prognosis of the disease also be discussed.