溃疡性结肠炎治疗药物研发

Progress of drug development for ulcerative colitis

随着对溃疡性结肠炎肠道免疫过程的深入了解,参与免疫反应的各个分子可作为新的治疗靶点。针对免疫过程的生物制剂和免疫抑制剂为中度至重度以及经传统治疗难以控制的溃疡性结肠炎的临床治疗带来希望。本文综述靶向免疫相关分子和肠道免疫过程的生物制剂和免疫抑制剂的研发进展。

Based on deeper understanding of the intestinal immune process of patients with ulcerative colitis,the biomolecules involved in immune system become new therapeutic targets.Biologics and immunosuppressants targeted on intestinal immune system bring a new hope to the ulcerative colitis patients for whom the traditional therapy is difficult to control.This review summarizes development progress of biologic and immunosuppressive agents in the treatment of ulcerative colitis.