期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

利拉鲁肽临床研究进展 被引量：17

Progress in clinical studies of liraglutide
原文传递
导出
摘要 利拉鲁肽是一种胰高血糖素样肽-1(GLP-1)类似物,通过激活GLP-1受体,以葡萄糖依赖性刺激胰岛素分泌并抑制胰高血糖素分泌,临床用于治疗2型糖尿病。本文综述利拉鲁肽的临床研究进展。 Liraglutide is an analogue of glucagon-like peptide-1（GLP-1）.It can stimulate glucose-dependent insulin secretion and inhibit glucagon secretion by activating the GLP-1 receptor.Generally,liraglutide is used for treatment of type 2 diabetes.This review describes the progress in clinical studies of liraglutide.
作者 陈群峰 王永祥
机构地区 上海交通大学药学院分子与系统药理学研究室
出处 《世界临床药物》 CAS 2013年第5期312-315,共4页 World Clinical Drug
关键词 利拉鲁肽 GLP-1受体激动剂 2型糖尿病 liraglutide glucagon-like peptide-1 receptor agonist type 2 diabetes
分类号 R587.1 [医药卫生—内分泌] R977.15 [医药卫生—药品]
  • 相关文献

参考文献17

  • 1中华医学会糖尿病学分会.中国2型糖尿病防治指南(2010年版)[J].中国医学前沿杂志(电子版),2011,6(3):54109.
  • 2Novo Nordisk increased operating profit by 34% in the first nine months of2012. (2012-10-31)[2013-01-12Jhttp://www. novonordisk. com/inves torsi seal sea. asp? sN ews TypeG VI D=&IMonth=0&IYear=20 12&sLanguageCode= en-GB& sSearchText=company+announcement&fb=se-6619&cat= se&sShowNewsItemGVID=0940e5ee-bdd4-43d6-bb4c- 72ae71 a62de 1 &sShowLanguageCode=en-GB.
  • 3Garber A, Henry R, Ratner R, et al. Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 mono): randomised, 52-week, phase III , double-blind, parallel-treatment trial[J]. Lancet, 2009, 373 (9662) : 473-481.
  • 4Marre M, ShawJ, Brandle M, et al. Liraglutide, a once-daily human GLP-l analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes (LEAD-l SV)[J]. Diabet Med,2009,26(3): 268-278.
  • 5Nauck M, Frid A, Hermansen K, et al. Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin in type 2 diabetes :the LEAD-2 study[J]'Diabetes Care,2009,32 (1) : 84-90.
  • 6Zinman B, GerichJ, BuseJB, et al. Efficacy and safety of the human glucagon-like peptide-l analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes mellitus (LEAD-4 Met+TZD)[J]. Diabetes Care, 2009, 32 (7): 1224-1230.
  • 7Russell-Jones D, Vaag A, Schmitz 0, et al. Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SV): a randomized controlled trial[J]. Diabetologia, 2009,52(10):2046-2055.
  • 8BuseJB, RosenstockJ, Sesti G, et al. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomized, parallel-group, multinational, open-label trial (LEAD-6)[J]. Lancet, 2009, 374 (9683): 39-47.
  • 9Rolin B, Larsen MO, Gotfredsen CF, et al. The long-acting GLP-l derivative NN2211 ameliorates glycemia and increases beta-cell mass in diabetic mice[J] . AmJ Physiol Endocrinol Metab, 2002, 283 (4): 745-752.
  • 10Garber A, Henry RR, Ratner R, et al. Liraglutide, a once-daily human glucagon-like peptide 1 analogue, provides sustained improvements in glycaemic control and weight for 2 years as monotherapy compared with glimepiride in patients with type 2 diabeteslJ]. Diabetes Obes Metab, 2011,13 (4): 348-356.

共引文献112

同被引文献180

  • 1李启富.多囊卵巢综合征与胰岛素抵抗[J].中华糖尿病杂志,2009,1(6). 被引量：1
  • 2郎江明,陈苹,魏爱生,陈发胜.新诊断2型糖尿病患者24小时血糖的波动特点[J].中华糖尿病杂志（1006-6187）,2005,13(1):43-45. 被引量：29
  • 3高虹,宁光.胰高血糖素样肽1的胰腺外作用研究进展[J].国际内科学杂志,2007,34(7):408-411. 被引量：25
  • 4邹雄,张利宁.分子免疫学与临床[M].济南:山东科学技术出版社,2010:410-411.
  • 5陈康庆,梅丽琴,林塘焕,等.多肽药物研究进展[C].中国药学大会暨第十届中国药师周论文集.2010.
  • 6Sun J, Chen X, Deng C, et al. Direct formation of giant vesicles from synthetic polypeptides[J]. Langmuir, 2007, 23(16): 8308-8315.
  • 7Nestor J J,Jr. The medicinal chemistry of peptides[J]. Curr Med Chern, 2009,16 (33): 4399-4418.
  • 8Sistiabudi R, Ivanisevic A. Patterning of polypeptides on a co\lagen?terminated tissue surface[J]. J Phys Chern Solid, 2007, 111(31): 11676- 11681.
  • 9Agut W, Taton D, Lecornmandoux S. A versatile synthetic approach to polypeptide based rod-coil block copolymers by click chemistry[J]. Macromolecules, 2007, 40 (16): 5653-5661.
  • 10休厄德N,贾库布克HD.肽:化学与生物学[M].刘克良,何军林,等译.北京:科学出版社,2005.

引证文献17

二级引证文献158

世界临床药物
2013年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部