万古霉素室间质量控制结果的评价

Evaluation of the external quality control for vancomycin

目的评价复旦大学附属华山医院抗生素研究所,卫生部抗生素临床药理重点实验室万古霉素血药浓度监测的室间质量控制水平。方法对1984—2011年该实验室参加英国国家外部质量评价体系(UK NEQAS)的万古霉素室间质量控制数据进行回顾性分析。结果该实验室的万古霉素质控样本的自测结果与其目标浓度有良好的相关性,万古霉素自测值=0.953 1×(万古霉素目标值)+0.475 7,R2=0.966 6;且自测值与目标值的偏差均在±30%之内。结论该实验室的万古霉素室间质量控制水平良好,可进行万古霉素的常规血药浓度监测。

Objective To evaluate the level of the external quality control of Institute of Antibiotics, Huasban Hospital, Fudan University, Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, in terms of therapeutic drug monitoring of vaneomycin. Methods Data of external quality assessment samples from the United Kingdom National External Quality Assessment Scheme from 1984 to 2011 were analyzed retrospectively. Results The observed level of vancomycin in our lab had a good linear correlation with its target value： observed value = 0. 953 1 × （target value） ＋ 0. 475 7, R^2 = 0. 966 6. The observed value of vancomycin was generally within its target value ± 30%. Conclusions The lab could conduct routine therapeutic drug monitoring for vancomycin with good quality evidenced by external quality assessment.