磷霉素对粪肠球菌的体外抗菌作用研究

Antimicrobial activity of fosfomycin and other antibiotics against Enterococcus faecalis

目的了解磷霉素对粪肠球菌的体外抗菌活性,并与其他6种抗菌药物进行比较。方法用琼脂稀释法检测磷霉素等7种抗菌药物对粪肠球菌的体外抗菌活性。结果分离的50株粪肠球菌标本中(25株分离自尿液标本,25株分离自血液标本),未发现对万古霉素、替考拉宁耐药的菌株,对青霉素均现耐药,对磷霉素敏感率98%、氨苄西林78%、红霉素8%、利福平24%。结论磷霉素对粪肠球菌的体外抗菌活性较强。

Objective To investigate the antimicrobial activity of fosfomycin and other antibiotics against Enterococcus faecalis. Methods Agar dilution method was employed to determine the susceptibility of Enterococcus faecalis to 7 antibiotics. Results The activity of 7 antibacterial agents against 50 Enterococcus faecalis （25 from urine, 25 from blood） showed susceptibility to vancomycin （ 100 % ）, teicomycin （ 100%）, fosfomycin （98 %）, penicillin （0）, ampicillin （78% ）, erythromycin （8 % ）, and rifampicin （24%）. Conclusions Fosfomyein is active for Enterococcus faecalis evidenced by in vitro susceptibility testing.