成人重症支原体肺炎肺泡灌洗液中TNF-α的作用及临床意义

Detection of TNF-α in bronchoalveolar lavage fluid in adult severe mycoplasma pneumonia and its clinical value

目的探讨肿瘤坏死因子(TNF-α)在重症支原体肺炎中的作用及临床意义。方法以我院呼吸科2007年1月—2012年8月收治的23例成人重症支原体肺炎的患者为重症组,以同时期收治的30例轻型支原体肺炎为对照组,取两组病例治疗前、后支气管肺泡灌洗液检测TNF-α水平。结果重症组TNF-α水平明显高于对照组(P<0.05),重症组治疗10 d后与治疗前比较肺泡灌洗液中TNF-α明显降低,差异有统计学意义(P<0.05)。结论 TNF-α在重症支原体肺炎中诱导细胞免疫发挥重要作用,对重症支原体肺炎的治疗及预后有重要指导意义。

Objective To investigate the level change in TNF-α in bronchoalveolar lavage fluid in adult patients with severe myco- plasma pneumonia. Methods From January 2007 to August 2012, 23 adult patients with severe mycoplasma pneumonia were en- rolled in trial group, and the control group included 30 patients with mitis mycoplasma pneumonia in the same period. The level α TNF-α in bronchoalveolar lavage fluid of the two groups were detected before and after treatment. Results The level of TNF-α was significantly higher in the trial group than in the control group at the time of admission （ P 〈 0.05 ） , and that of TNF-α in the trial group was significantly lower after 10 days＇ treatment than before treatment （ P 〈 0.05 ）. Conclusion TNF-α takes part in the in- flammation activity in adult patients with severe mycoplasma pneumonia, and it has important clinical value in treatment and progno- sis of adults＇ severe mycoplasma pneumonia.