应用代血浆部分代替血浆进行人工肝治疗重型肝炎的探讨

Study of artificial liver treatment on patients with severe hepatitis with plasma substitutes partly instead of plasma

目的观察应用代血浆部分代替血浆进行人工肝血浆置换治疗重症肝炎的疗效。方法选取64例重症肝炎病人,随机分为代血浆+新鲜血浆组(观察组)和单纯血浆组(对照组),各治疗患者32例。结果两组患者治疗后与治疗前比较,症状改善肝功能明显好转(P<0.01,P<0.05),两组治疗后,临床疗效比较差异无统计学意义(P>0.05)。结论血浆置换是一种有效的人工肝支持疗法,新鲜冰冻血浆是理想的置换液,在血浆紧缺的情况下,可用代血浆部分代替血浆进行人工肝血浆置换治疗重型肝炎。

Objective To investigate the efficacy of artificial liver treatment on patients with severe hepatitis with plasma substitutes partly instead of plasma. Methods A total of 64 patients with severe hepatitis were enrolled and assigned into two groups random- ly. 32 patients received plasma substitutes combined with fresh plasma in observation group and the other received simple plasma in control group. Results Compared with before treatment, patients＇ symptoms relieved and liver function improved obviously （ P 〈 0.01 ,P 〈 0.05）. There was no difference on clinical efficacy （ P 〉 0.05 ）. Conclusion Plasma exchange is an effective way of artificial liver support treatment. The fresh frozen plasma is a kind of ideal replacement fluid, while it is also obviously effective to apply artificial liver treatment on the patients with severe hepatitis with plasma substitutes partly instead of plasma on the lack oi plasma.