丙泊酚与咪达唑仑在急性脑出血手术中的麻醉效果

Effect of propofol and midazolam anesthesia in surgery of acute cerebral hemorrhage

目的研究分析丙泊酚与咪达唑仑在急性脑出血手术中的麻醉效果。方法选取我院收治的96例急性脑出血患者作为临床研究对象，应用电脑随机号的方式将96例患者分为试验组和对照组，每组均48例患者。试验组患者施行丙泊酚药物麻醉。对照组患者施行咪达唑仑药物麻醉。记录试验组和对照组患者在围术期的平均动脉压（MAP）、心率（HR）、血红蛋白值（Hb）、动脉和颈静脉的血氧饱和度和血氧分压，和对手术前后临床神经功能缺损程度平定，并进行比较分析。结果使用丙泊酚的试验组患者，其平均动脉压（MAP）、心率（HR）、血红蛋白值（Hb）、血氧饱和度和血氧分压状况较术前有了较大改善，明显优于采用咪达唑仑的对照组，具有统计学意义（P〈0．05）。对照组的神经损伤情况明显优于对照组，具有统计学意义（P〈0．05）。结论丙泊酚较咪达唑仑在急性出血手术中具有更好的麻醉效果，能有效地改善保护脑组织。

Objective To study analysis of propofol and midazolam in the acute cerebral hemorrhage surgery anesthetic effect. Methods 96 patients with acute cerebral hemorrhage patients select our hospital as a clinical study, the application of computer - generated random number of 96 patients were divided into experimental and control groups, each group of 48 patients. The experi- mental group underwent propofol drug anesthesia. The control group underwent midazolam drug anesthesia. Record of the test group and a control group of patients in the perioperative mean arterial pressure （ MAP）, heart rate （ HR）, hemoglobin value （ Hb）, ar- terial and jugular venous oxygen saturation and blood oxygen pressure, and after surgery with pacification of the degree of neurologi- cal deficit and comparative analysis. Results Propofol subgroup, the mean arterial pressure （ MAP）, heart rate （ HR）, hemoglo- bin value （Hb） , oxygen saturation and blood oxygen conditions have been greatly improved compared with the preoperative obvious superior to midazolam control group, P 〈 0.05, statistically significant. The nerve injury situation of the control group was signifi- cantly better than the control group, P 〈 0.05 considered statistically significant. Conclusion Propofol compared with midazolam in the acute hemorrhage surgery has better anesthetic effect, which can effectively improve the protection of brain tissue.