急性脑出血的血肿扩大与血清总胆固醇和低密度脂蛋白胆固醇的关系

Relation of enlarged hematoma with TC and LDL-C in patients with acute intracerebral hemorrhage

目的研究急性脑出血患者血肿扩大与血清TC、LDL-C水平的关系。方法选择急性脑出血患者144例,入院后即刻测量血压,检测血糖,进行美国国立卫生研究院脑卒中量表评分,即刻和24h行2次CT检查,测量并计算血肿体积,以第二次CT血肿量比第一次增加33%定义为血肿扩大,分为血肿扩大组72例和对照组72例,发病6h内抽血检测TC、LDL-C数值。结果血肿扩大组年龄、收缩压、舒张压、血糖明显高于对照组,TC、LDL-C明显低于对照组(P<0.05)。logistic回归模型分析筛选出的变量为:LDL-C(OR=0.001,95%CI:0.001～0.024,P<0.001)、TC(OR=0.057,95%CI:0.004～0.863,P=0.0322)、血糖(OR=1.851,95%CI:1.219～2.810,P=0.0038)、收缩压(OR=1.120,95%CI:1.021～1.229,P=0.0165)、舒张压(OR=1.152,95%CI:1.052～1.262,P=0.0023)。结论急性脑出血患者血肿扩大与TC、LDL-C水平有关。

Objective To study the relation of enlarged hematoma with TC and LDL-C in patients with acute intracerebral hemorrhage. Methods One hundred and forty-four patients with acute intracerebral hemorrhage were included in this study. Their blood pressure and blood glucose level were measured at admission. The patients underwent CT at admission and 24 h after admission. The volume of hematoma was measured. Enlarged hematoma was defined when the volume of he- matoma increased 33% in the second CT. The patients were divided into enlarged hematoma group （n=72） and control group （n=72）. Their serum TC and LDL-C levels were measured with- in 6 h after acute intracerebral hemorrhage. Results The age was older,the SBP,DBP and blood glucose level were significantly higher, the serum TC and LDL-C levels were significantly lower in enlarged hematoma group than in control group （P 〈 0.05）. Logistic regression model analysis showed that the serum levels of LDL-C and TC and blood glucose,and the SBP and DBP were sig- nificantly higher in enlarged hematoma group than in control group （OR=-0. 001,95%CI.0. 001-- 0. 024,P〈0.001;OR=0. 057,95%CI：0. 004--0. 863,P=0. 0322;0R= 1. 851,95%CI. 1. 219-- 2. 810,P=0. 0038;OR=1. 120,95%CI.1. 021--1. 229,P=0. 0165;OR= 1. 152,95%CI.1. 052-- 1. 262, P=0. 0023）. Conclusion Enlarged hematoma is related with the serum levels TC and LDL-C in patients with acute intracerebral hemorrhage.