脑梗死患者动脉斑块稳定性与血清超敏C-反应蛋白的关系

Relationship between serum high-sensitivity C-reactive protein and carotid artery plaque stability in cerebral infarction patients

目的 探讨血清超敏C-反应蛋白（hs-CRP）与颈动脉斑块稳定性的关系。方法 将155例经头部CT/MRI确诊的脑梗死患者按颈部动脉超声分为非斑块组、颈动脉斑块组（不稳定型斑块亚组和斑块稳定亚组）,检测患者血清hs-CRP、TC、LDL-C、HDL及HDL-C、血肌酐及尿酸。采用多因素logistic回归分析。结果 仅hs-CRP浓度是颈动脉斑块发生的危险因素（RR=1.301,95% CI=1.041～1.599,P=0.010）;不稳定型斑块亚组患者的血清hs-CRP显著高于非斑块组和稳定型斑块亚组。结论 血清hs-CRP的检测及颈动脉超声可对斑块不稳定者做早期诊断与干预。从而降低脑梗死的发生率和病死率。

Objective To explore the relationship between high-sensitivity C-reactive protein （hs-CRP） and carotid plaque stability.Methods 155 cases confirmed cerebral infarction by head CT/MRI were divided into group without plaque,plaque vulnerability group and plaque stability group.Serum levels of hs-CRP,lipids,creatinine and uric acid were measured.Results Logistic regression analysis was used to analyze the parameters of all the patients′ age,serum TC,LDL-C,HDL and HDL-C,serum creatinine,hs-CRP and uric acid.Only hs-CRP level was the risk factor of carotid plaque（RR=1.301,95% CI=1.041～1.599,P=0.010）.Serum hs-CRP level in patients with vulnerable plaque was significantly higher than the group without plaque and plaque stability group.Conclusion The detection of serum hs-CRP and carotid artery ultrasound can make early diagnosis and intervention to reduce the incidence and mortality of cerebral infarction for plaque instability patients.