庆大霉素前庭损害报警耳聋的实验研究

Experimental observation on Gentamycin vestibular damage alarming deafness

目的观察庆大霉素对前庭及耳蜗的损害。方法对肌肉注射庆大霉素（250mg·kg－1／d）连续3天和7天的两组豚鼠进行前庭和耳蜗功能与形态的观察。结果发现用药3天仅影响前庭，而用药7天则前庭和耳蜗均受损害，提示庆大霉素早期损害前庭的特点可以报警耳蜗的损害。结论因此，在应用庆大霉素过程中，发现前庭功能改变时，如能及时停药，可以避免耳聋的发生。

Objective To observe the in jury of vestibular and cochlear end organ causedby Gentamycin. Method Two groups of guinea pigs, one were intramuscularly injected withGentamycin in a dosage of 250mg/kg per day for a continuous 3 days and the other for a continu-ous 7 days. Then all animal's vestibular and cochlear functions were tested and the cochleas wereharvested for a pathological examination. Result We found that guinea pigs had only vestibulardisfunction in 3 day group and had both vestibular and cochlear disorders in 7 day group- Thepathological findings were also consistent with the tested results. It seems that the early vestibu-lar in jury produced by Gentamycin can be as a sign of sensory-neural deafness. Conclusion Inclinical Gentamycin administration, it is very important to stop administrating immediately whenvestibular symptoms appear, otherwise, an unavoidable deafness will be followed.[