降钙素原在新生儿感染疾病中的应用

Clinical application of Procalcitonin in neonatal infection

目的评价降钙素原(PCT)在诊断新生儿感染性疾病中的临床应用。方法收集2012年1—12月被我院NICU收治的新生儿感染性疾病138例,并根据感染严重度评分(SSS)将其分为重症感染组55例、一般感染组83例,同时选同期非感染新生儿病例50例,应用半定量免疫色谱法分别测定三组的血清PCT水平,并与血清C-反应蛋白(CRP)的诊断结果相比较。结果重症感染组的PCT均明显高于另两组(P<0.05或P<0.01),一般感染组的PCT阳性率较非感染组间高(P均<0.05);PCT对新生儿重症感染诊断的敏感性为87.3%明显高于CRP的56.4%(P<0.05),二者特异度差异并无显著性。结论 PCT可作为新生儿感染疾病的一项灵敏检测指标,尤其适用于的重症感染新生儿的诊断和治疗,较CRP更具临床应用价值。

Objective To evaluate procalcitonin（PCT） applied in the diagnosis of neonatal infection.Methods The selection of 138 cases of neonatal infectious diseases whcih were collected from January 2012 to december 2012 were divided into 55 cases of severe infection group and 83 cases of general infection group two groups according to the infection severity score,electing 50 cases of non-infected newborns as the control group.3 groups of the level of serum PCT were tested by Semiquantitative immune chromatography,compared to the level of serum C-reactive protein（CRP）.Results The level of serum PCT in severe infection group was significantly higher than the other two groups＇s（P0.05 or P0.01）,the level of serum PCT in the general infection group was higher than the control group＇s（P0.05）;The sensitivity of PCT and CRP for diagnosis of neonatal infection was 87.3% and 56.4% respectively,there was no significant difference（P0.05）.Conclusions PCT is more sensitive than CRP and neonatal infection can be diagnosed and treated much earlier,more sensitively by using the detection of PCT.