皮肤血管炎患者血浆TXB_26-Keto-PGF_(1α)水平的检测

Plasma TXB_2 and 6-Keto-PGF_(1α) Levels Examination in Patients with Cutaneous Vasculitis

目的 探讨皮肤血管炎患者血浆TXB2 、6 Keto PGF1α水平的变化与病情的关系。方法 采用放免法对结节性红斑、慢性游走性结节性红斑、结节性血管炎患者治疗前后血浆TXB2 、6 Keto PGF1α含量进行了动态检测并与正常对照组进行对比。结果 皮肤血管炎患者血浆TXB2 水平在治疗前后与正常对照组差异无显著性意义 ,而 6 Keto PGF1α在治疗前高于正常对照组 ,当皮损消退后其水平恢复正常。结论 在皮肤血管炎存在内皮细胞的损伤 ,当皮损消退后 ,受损的内皮细胞得到了修复。

Objective In order to inquire into association of plasma TXB 2,6 Keto PGF 1α levels and state of cutaneous vasculitis.Methods Plasma TXB 2,6 Keto PGF 1α levels were examined by radioimmunoassay in cutaneous vasculitis including erythema nodosum,chronic migrant erythema nodosum and nodular vasculitis.Plasma TXB 2,6 Keto PGF 1α levels before therapy were compared with that after therapy,also compared to normal control.Results Level of TXB 2 was unchanged.The level of 6 Keto PGF 1α before therapy was higher than that of normal control.When the rashes disappeared,the 6 Keto PGF 1α level returned to normal.Conclusion Endothelium was damaged in cutaneous vasculitis. When the rashes disappeared,the damaged endothelium had been repaired.