中国北方汉族人群尾加压素Ⅱ基因多态性与原发性高血压相关性研究

Role of UrotensinⅡ gene polymorphisms in susceptibility to the development of essential hypertension in a Northern Han Chinese population

目的:研究高血压候选基因尾加压素Ⅱ(urotensinⅡ,UTS2)在中国北方汉族人群的分布,探讨UTS2基因Ser89Asn多态性与原发性高血压(essential hypertension,EH)的关系。方法:采集健康体检人群临床资料,分析体质量指数、血脂及血糖等临床指标,同时调查受检者吸烟和饮酒等生活习惯;TaqMan-MGB法分析UTS2基因Ser89Asn多态性在中国北方汉族人群(样本总数1 146例,其中EH病患者682例,血压正常的健康体检者464例)的分布及其与临床指标的相关性。结果:结果显示:UTS2的Ser89Asn基因型(P=0.037)和等位基因频率(P=0.039)在两组总体的差异具有统计学意义,性别亚组差异无统计学意义;调整其他影响因素后,Logistic回归模型分析显示,UTS2 EH总体和性别亚组的Ser89Asn基因多态性与EH无关。结论:在中国北方汉族人群中,未见UTS2基因Ser89Asn突变与原发性高血压相关。

Objective：The aim of the present study was to explore the potential association between the UrotensinⅡ（UTS2） gene polymorphisms and essential hypertension（EH） risk in the Northern Han Chinese population.Methods： This study included 682 hypertensive subjects and 464 healthy control subjects in the Northern Han Chinese.Genotyping was performed to identify the Ser89Asn polymorphisms of the UTS2 gene.Results： Significant associations were found in genotype frequencies（P=0.037） and in allele frequencies（P=0.039） between hypertensive and normotensiv groups（total）.The data were subjected to logistic regression analysis after adjusting for confounding risk variables.No Significant associations were found between hypertensive and normotensiv groups（in both total and gender subgroup）.Conclusion： Our research indicated that there was no significant association between Ser89Asn polymorphism of the UTS2 gene and hypertension in the Northern Han Chinese population.