加替沙星与左氧氟沙星治疗急性细菌感染的疗效比较

Comparison of the effect of gatifloxacin and levofloxacin for treating acute bacterial infection

目的 比较加替沙星与左氧氟沙星治疗急性细菌感染的疗效,评价加替沙星治疗急性细菌感染的有效性和安全性。方法 将呼吸系统和泌尿系统感染的患者228例根据数字表法随机分为A组和B组,每组114例。A组给予加替沙星200 mg加入5%葡萄糖注射液100 ml静脉滴注;B组给予左氧氟沙星200 mg加入5%葡萄糖注射液100 ml静脉滴注。两组均予2次/d,疗程均为7~14 d。观察两组疗效和细菌清除率以及不良反应。结果 A组痊愈率、总有效率分别为68.4%、93.0%,B组分别为66.7%、90.3%,差异均无统计学意义（χ2=0.184、0.213,均P〉0.05）。A组细菌清除率、细菌药物敏感试验敏感率分别为89.4%、78.8%,B组分别为77.2%、70.3%,差异均有统计学意义（χ2=4.812、4.236,均P〈0.05）。A组不良反应发生率为7.0%,B组为6.1%,差异无统计学意义（χ2=0.672,P〉0.05）。结论 加替沙星治疗急性细菌引起的呼吸系统、泌尿系统感染疗效显著,不良反应较低,治疗效果与左氧氟沙星无明显差异,值得临床推广应用。

Objective To compare the effect of gatifloxacin and levofloxacin for treating acute bacterial infection.Methods According to the digital table,228 patients with respiratory or urinary tract infections were randomly divided into group A and group B,114 cases in each group.Group A was given gatifloxacin 200mg,adding 5% glucose injection 100ml intravenous drip injection twice daily;Group B was treated with levofloxacin 200mg,by adding 5% glucose injection 100ml intravenous infusion twice daily.The treatment course lasted 7~14 days.The clincal effect, bacterial clearance rate and adverse reactions of the two groups were observed.Results The cure rate and total effective rate of group A was 68.4%,93.0%,respectively,which of group B was 66.7%,90.3%,respectively,the differences were statistically significant （χ2=0.184,0.213,all P〉0.05）.The bacterial clearance rate and bacterial drug sensitivity test sensitivity was 89.4%,78.8%,respectively,which of group B was 77.2%,70.3%,respectively,the differences were all statistically significant （χ2=4.812,4.236,all P〈0.05）.The incidence rate of adverse reactions of group A was 7.0%,which of group B was 6.1%,there was no statistically significant difference （χ2=0.672,P〉0.05）.Conclusion Gatifloxacin has better effect and lower adverse reactions in the treatment of acute bacterial respiratory or urinary tract infections,and there is no significant difference compared with levofloxacin treatment,and it is worthy of clinical application.