上海市静安区性病门诊50岁以上男性就诊者HSV-2感染率及其影响因素研究

Prevalence and influencing factors analysis of HSV-2 infection among male STD clinic attendants aged over 50 years in Jing' an District of Shanghai City

目的调查研究上海市静安区50岁及以上男性性病门诊患者2型单纯疱疹病毒(HSV-2)感染率及其影响因素。方法连续入选2011年3—9月首次到华山医院及其分院静安区中心医院性病门诊50岁及以上男性就诊者作为研究对象,在其知情同意的情况下进行问卷调查,并采集血液标本进行HSV-2 IgG抗体和人类免疫缺陷病毒(HIV)抗体检测。结果共157人首次前来就诊并知情同意接受本调查,平均年龄(60.1±7.7)岁。HIV阳性1人(0.6%),HSV-2阳性52人(33.1%)。多因素Logistic回归分析显示:婚姻状况(OR=0.27,95%CI:0.10～0.73)、文化程度(小学及以下OR=0.23,95%CI:0.07～0.77;初中OR=0.47,95%CI:0.21～1.04)、是否退休(OR=2.68,95%CI:1.23～5.85)以及有无子女(OR=0.08,95%CI:0.01～0.88)是50岁及以上男性HSV-2感染的影响因素。结论上海市静安区50岁及以上性病门诊男性就诊者中HSV-2感染率高,有必要加强该人群HSV-2防治工作。

Objective To explore the prevalence and influencing factors of herpes simplex virus type 2（HSV-2） infection among male STD clinic attendants aged over 50 years in Jing＇ an District of Shanghai.Methods Males STD clinic attendants aged over 50 years in Huashan Hospital and Jing＇ an District Central Hospital during March to September in 2011 were participated in a questionnaire interview after informed consent given,and blood samples were collected for HSV-2 IgG antibody and HIV antibody test.Results The average age of 157 participants was（60.1±7.7） years.Only one of them（0.6%） was HIV positive and 52（33.1%） were HSV-2 positive.Multiple logistic regression analysis indicated that HSV-2 infection among male STD clinic attendants aged over 50 years was significantly correlated with their marital status（OR=0.27,95%CI： 0.10-0.73）,education level（primary and lower：OR=0.23,95%CI： 0.07-0.77;junior high school：OR=0.47,95%CI： 0.21-1.04）,retiring status（OR=2.68,95%CI： 1.23-5.85） and number of children（OR=0.08,95%CI：0.01-0.88）.Conclusion The HSV-2 prevalence among male STD clinic attendants aged over 50 years in Jing＇ an District of Shanghai was very high,and it is necessary to carry out HSV-2 prevention and control in this population.