1-溴-3-氯-5,5-二甲基-2,4-咪唑啉啶二酮的合成

Synthesis of 1-bromo-3-chloro-5,5-dimethylhydantoin

用溴化钠代替溴酸钠或溴素提供一个卤原子,在碱性条件下5,5-二甲基海因与氯气发生卤化反应合成1-溴-3-氯-5,5-二甲基海因。工艺最佳反应条件为:pH为9.0,反应温度5～10℃,反应3h,保温1h,BCDMH的收率可达98%以上。

Using NaBr substitute NaOBr or Br2 offer a halogen atom, BCDMH was synthesized from DMH and Cl2 as alkalescence condition. The optimum reaction conditions were as follows： pH = 9.0, reaction temperature 5 - 10 ℃, reaction time for 3 hours , keeping warm for 1 hours,and the yield of BCDMH was over 98%.