乙哌立松联合普罗喹宗治疗紧张性头痛疗效观察

The efficacy of proquazone combined with eperisone in treatment of tension headache

目的 观察乙哌立松联合普罗喹宗治疗紧张性头痛的临床疗效以及不良反应的发生情况。方法 285例紧张性头痛的患者按数字表法随机分成A、B、C三组,A组95例患者单纯使用乙哌立松治疗,B组95例患者单纯采用普罗喹宗治疗,C组95例患者联合使用乙哌立松和普罗喹宗法进行治疗。观察患者头痛发作的频率、发作平均时间,并对患者进行VAS评分,从而评价患者症状缓解的情况。结果 C组患者治疗后头痛的发作频率、发作持续时间及VAS评分分别为（2.01±1.02）次/周、（4.28±2.14）h、（3.42±1.03）分,显著小于A组、B组（t=8.682、7.879、13.396、14.140、16.408、21.481,均P＜0.05）。C组不良反应发生率37.89%,与A组（36.84%）、B组（34.74%）差异均无统计学意义（均P＞0.05）,但C组嗜睡淡漠的发生率显著高于A、B组（χ2=34.381、13.821,均P＜0.05）。结论 乙哌立松联合普罗喹宗可以有效减少紧张性头痛患者发作的频率、持续时间及疼痛程度,不会增加不良反应的发生,具有较好的安全性,值得推广。但因中枢抑制作用,不适用于高危险职业或户外操作人员。

Objective To observe the clinical efficacy and adverse reactions of proquazone combined with eperisone in treating tension headache.Methods 285 tension headache patients in our hospital from 2009 to 2011 were randomly divided into A,B,C three groups.Group A with 95 cases used only eperisone treatment,while B group with 95 cases used only proquazone.Group C with 95 cases received eperisone combined with proquazone treatment.The frequency of migraine attacks,the attack average time,and VAS score of patients were observed.Results The headache frequency,seizure duration and VAS score of group C was （2.01±1.02）times/week,（4.28±2.14）h,（3.42±1.03）points,which were significantly less than those in group A and group B（t=8.682,7.879,13.396,14.140,16.408,21.481,all P〈0.05）.The incidence rate of adverse reaction of group C was 37.89%,that in group A was 36.84%,and group B was 34.73%.The difference among them was not statistically significant（P〉0.05）.But the incidence rate of drowsiness and indifferent symptom in group C was significantly higher than A and B group.The difference was statistically significant（χ2=34.381,13.821,all P〈0.05）.Conclusion Eperisone combined with proquazone could treat tension headaches well,because it can effectively reduce the frequency of migraine attacks in patients as well as the degree of pain.And it could also alleviate the patients′ symptoms.In addition,the combination therapy did not increase the incidence rate of adverse reactions in patients.So it has better security and good cilinical promotion.But it couldn′t be proscribed to the people with high-risk occupation for its suppression to CNS.