手足口病复发436例临床分析

Analysis of the clinical features of 436 cases of recurrence hand,foot and mouth disease

目的 分析手足口病复发患儿的临床特点及治疗方法。方法 回顾性分析436例手足口病复发患儿的临床资料,对其在临床表现、实验室检查等方面的特点进行总结分析。结果 复发患儿年龄以2～5岁多见,共211例患儿,比例为48.4%;所有复发患儿皮疹均在手足口或臀部出现,有104例在肘膝上下出现皮疹,有9例在躯干部位出现皮疹;复发患儿易出现呼吸系统、消化系统、心血管系统及神经系统并发症,其中呼吸系统并发症最为常见,约占76.4%,其次为消化系统,约占18.5%。患儿复发时间主要集中在4～6月份,共有251例患儿,约占总复发人数57.6%;时间间隔以3～12个月为多见,共有326例复发病例,约占74.8%。结论 手足口病再次复发病例临床表现不典型,主要为普通型,重症患儿少,易合并呼吸系统、消化系统疾病,早期发现和诊断是治疗的关键。

Objective To analyze the clinical characteristics and treatment methods of recurrence hand,foot and mouth disease （HFMD）.Methods The clinical data of 436 HFMD patients were retrospectively analyzed.The characteristics of clinical manifestations,laboratory tests were analyzed.Results There were a total of 211 patients,accounting for 48.4%,the recurrence age was 2 to 5 years old.All relapsed patients rash appeared in the hand,foot and mouth or buttocks,there were 104 cases of rash appeared in elbow and knee,9 cases appeared in the torso.The recurrence patients proned to occur respiratory system,digestive system,cardiovascular system and nervous system complications.Respiratory complications were the most common,accounting for about 76.4%,followed by the digestive system,accounting for 18.5%.The distribution of relapse in children with time to recurrence and recurrence interval analysis found mainly in April to June,a total of 251 patients,the total relapse proportion was 57.6%;time interval was more common between 3 months to 12 months,a total of 326 cases of recurrence,accounting for 74.8%.Conclusion Clinical manifestations are not typical in recurrence HFMD patients,most are ordinary,less critically ill patients,it is easy to merge the respiratory system,digestive system complications.Early detection and diagnosis is the key to the treatment.