原发性高血压患者血清抵抗素与动脉粥样硬化的临床研究

Clinical research on serum resistin and atherosclerosis in essential hypertension

目的研究原发性高血压患者血清抵抗素与动脉粥样硬化的相关性。方法选用原发性高血压患者103例为病例组,正常健康查体者100例为对照组。所有受试者均测量血压、腰围、体质量指数(BMI),检测空腹血糖、血脂、颈总动脉内中膜厚度(IMT)、管腔内径和斑块厚度、性质、数量,应用酶联免疫吸附测定(ELISA)检测血清高敏C反应蛋白(hsCRP)、抵抗素。结果原发性高血压患者IMT、hsCRP、抵抗素显著高于正常对照组,分别为IMT(2.3±0.7)分vs(0.4±0.1)分;hsCRP(5.7±1.5)mg/L vs(1.9±0.5)mg/L;抵抗素(3.1±0.3)ng/L vs(1.9±0.5)ng/L(均P<0.01)。相关性分析显示,高血压组IMT与hsCRP(r=0.500)、抵抗素(r=0.494)均呈正相关,抵抗素与hsCRP(r=0.396)呈正相关(均P<0.01)。多元线性回归分析显示,年龄、收缩压、hsCRP、抵抗素、BMI、低密度脂蛋白胆固醇与IMT呈正相关。结论血清抵抗素与高血压动脉粥样硬化密切相关,抵抗素可能通过炎症作用促进动脉粥样硬化的形成和发展。

Objective To investigate the correlation between resistin and atherosclerosis in essential hypertension（EH）. Methods The experimental group included 103 cases from consecutive patients diagnosed as EH. The control group included 100 healthy subjects who accepted physical examination in the same setting. Blood pressure, waist circumference and body mass index（BMI） were measured and calculated. Carotid artery intima-media thickness （IMT） ,lacunar inner diameter and thickness, features,number of plaques were detected, then blood samples were taken for measurement of biochemical indicators such as fasting plasma glucose,blood lipid. ELISA was used to detect high sensitive C reactive protein（hsCRP） ,resistin. Results IMT,hsCRP, resistin in EH differed significantly from those in the control group,IMT（2.3±0.7） scores vs （0.4±0.1） scores;hsCRP（5.7±l.5）mg/L vs （1.9±0.5） mg/L resistin（3.1±0.3） ng/L vs （1.9±0.5） ng/L（ P 〈0.01）. IMT and serum hsCRP（ r =0. 500）,resistin（ r =0. 494） correlated positively in the experimental group（all P 〈0.01）. There was also positive linear correlation between resistin and hsCRP. Multiple regression analysis demonstrated that IMT correlated positively with age,systolic blood pressure, hsCRP,resistin,BMI and low density lipid cholesterol. Conclusion The result suggests that the resistin is associated with atherosclerosis in EH patients. The effect of resistin on atherosclerosis worths attention.