摘要
目的 探讨雌激素受体（ER）、孕激素受体（PR）和人类表皮生长因子受体-2（CerbB-2）在甲状腺乳头状癌中的表达及其与甲状腺乳头状癌生物学行为之间的关系.方法 采用免疫组织化学法检测89例甲状腺乳头状癌标本和13例结节性甲状腺肿标本中ER、PR和CerbB-2的表达.结果 ER、PR和CerbB-2在甲状腺乳头状癌中的表达率分别为50.56％（45/89）、43.82％（39/89）、24.72％（22/89）,在结节性甲状腺肿中的表达率分别为15.38％（2/13）、7.69％（1/13）、0,两组比较差异有统计学意义（x2=5.649,P=0.017; x2=6.211,P=0.013; x2=4.097,P=0.043）.PR的表达在无淋巴结转移者中阳性率为56.26％（26/46）,较有淋巴结转移者的30.23％（13/43）明显增高,差异有统计学意义（x2=6.239,P=0.012）.结论 ER、PR、CerbB-2在甲状腺乳头状癌中的表达明显增高,对三者进行检测可以为甲状腺乳头状癌的早期诊断和预后提供帮助.
Objective To explore the expressions of ER,PR and CerbB-2 in human papillary thyroid carcinoma,and their correlation with the clinical features.Methods The expressions of ER,PR and CerbB-2 were detected by immunohistochemistry in 89 papillary thyroid carcinoma samples and 13 nodular goiter samples.Results In papillary thyroid carcinoma samples,ER,PR and CerbB-2 were detected for 50.56 %（45/89）,43.82 % （39/89）,24.72 % （22/89）,respectively.In nodular goiter,ER,PR and CerbB-2 were detected for 15.38 % （2/13）,7.69 % （1/13）,0,respectively,there were significant differences between the two groups （x2 =5.649,P=0.017,x2 =6.211,P=0.013,x2 =4.097,P=0.043）.The positive rates of PR were 56.26 %（26/46） in without lymph node metastasis,compared with those lymph node metastasis 30.2 3% （13/43） were significantly higher,the difference was statistically significant （x2 =6.239,P =0.012）.Conclusion The expressions of ER,PR and CerbB-2 are significant higher in papillary thyroid carcinoma.The detection of ER,PR and CerbB-2 might be helpful for early diagnosis and prognosis of papillary thyroid carcinoma.
出处
《肿瘤研究与临床》
CAS
2013年第5期339-341,共3页
Cancer Research and Clinic
