急性白血病150例长期生存患者的临床分析

Analysis of 150 long-term survival patients with acute leukemia

目的 :总结上海市近 10年来急性白血病 15 0例长期生存患者的临床资料。方法 :采用病例分析方法。结果 :15 0例 5年以上长期生存者中 ,急性粒细胞白血病 (AML) 6 5例 ,急性淋巴细胞白血病 (AL L) 81例 ,其它类型 4例。M3和 L1 的病例数较多。长期生存组患者发病时较年轻 ,2～ 10岁儿童占 33.3% ,青壮年约占 5 0 %。与非长期生存组患者比较 ,长期生存患者白细胞数较低 ,血小板数较高 (均为 P <0 .0 5 )。AML总化疗时间 >3年或≤ 3年中位生存时间无差别 ,AL L化疗时间≤ 3年者中位生存时间较短。结论 :白血病类型、年龄、白血病负荷指标 WBC及血小板数是影响急性白血病患者长期生存的重要因素。

Objective:To sum up the clinical characteristics in 5 year long term survivors with acute leukemia.Methods:Clinical case report was used.Results:Between 1984 and 1994, 1028 patients with acute leukemia were enrolled in Shanghai. One hundred fifty patients entered 5 year long term survival group, 65 with acute myeloid leukemia and 81 with acute lymphocytic leukemia. M 3 and L 1 subtype had better prognosis. About 33.3 % of 150 long term survivors was children aged 2 to 10 years, 50% was adults aged 21 to 60 years. The long term survivors had lower white blood cell count and higher blood platelet count compared to other patients. The total chemotherapy time was recommended 3 years for acute myeloid leukemia and 3~5 years for acute lymphocytic leukemia.Conclusion:The subtype, age,white blood cell count,platelet count are important factors which could influent the long survive time of acute leukemia patients.