孕晚期使用乙肝免疫球蛋白对阻断乙肝病毒母婴传播的效果研究

The effect of application of hepatitis B hyper-immune globulin on preventing the transmission of hepatitis B virus from the mother to infant in late pregnancy

目的:研究乙肝免疫球蛋白(HBIG)阻断乙型肝炎病毒(HBV)母婴传播的效果。方法:根据知情自愿原则,将本院2010～2011年度654例HBsAg阳性孕妇所分娩的新生儿分为实验组、对照组。实验组327例孕妇于妊娠28周起,每4周肌肉注射HBIG 200IU。对照组327例孕妇,不使用HBIG。两组新生儿均在出生后24h内各注射HBIG 100IU及乙肝疫苗,并于1,6个月龄肌肉注射乙肝疫苗。结果:12月龄时,实验组婴儿HBsAg阳性率(2.75%)低于对照组(6.42%),差异有统计学意义(P<0.05);抗-HBsAg阳性率实验组(87.46%)高于对照组(78.59%),差异有统计学意义(P<0.05)。结论:HBsAg阳性孕妇孕晚期使用乙肝免疫球蛋白能够降低乙肝病毒母婴传播率。

Objective： To study the effect of hepatitis B hyper-immune globulin （HBIG） on preven- ting the transmission of hepatitis B virus （HBV） from mothers to infants. Methods： Based on the principle of volunteer and informed consent, neonates given birth in our hospital by 654 cases of hepatitis B surface antigen （HBsAg） positive pregnant women from 2010 to 2011 were divided into the experimental group and the control group. 327 pregnant women in theexperimental group were intramuscularly injected with 200 IU of HBIG every four week from the 28th week of pregnancy, while the other 327 women in the control group did not apply HBIG. The neonates in both groupswere injected with 100 IU of HBIG and hepatitis B vaccine 24 hours after being born, and were in- tramuscularly injected with hepatitis B vaccine when they were 1-month and 6-month old. Results： Till the neonates were 12-month old, HBsAg positive rate for those in the experimental group was 2.75%, lower than that of the control group （6.42%）, which was of statistical difference （P〈0.05） ; while the anti-HbsAg positive in the experimental group was 87.46%, higher than that of the control group （78.59%）, whichwas of significant difference （P〈0.05）. Conclusion： The ap- plication of HBIG for HbsAg women in late pregnancy can reduce the transmission rate of HBV from mothers to infants.